The role of reactive oxygen species (ROS) in the cardiovascular system is Janusfaced.
Whereas low concentrations of ROS are involved in variety of physiological
signalling events, oxidative stress resulting from deregulated overproduction of ROS
and/or impaired antioxidant defences contributes to cardiovascular disease. The
actions of ROS in the cardiovascular system are a fascinating topic, not only for the
basic science researcher but also for the clinician who is interested in seeking new
therapies for his patients suffering from cardiovascular disease. The current book
provides a comprehensive overview of the molecular mechanisms and pathophysiological
settings in which chronic and detrimental oxidative stress arises within
the heart and vasculature. The book also considers currently discussed strategies
in avoiding chronic redox stress resulting from exposure to risk factors or various
cardiovascular interventions.